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The gluteal aponeurosis insertions are on the posterior iliac bone, the sacral bone, and the coccyx bone, and on the lateral limit inserts on the greater trochanter and extends to the iliotibial line

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The production of the oncogenic metabolite 2-hydroxyglutarate (2-HG), whose cumulative concentration can surpass the normal level by more than a thousandfold, is abnormally catalyzed by mutations in IDH1 (R132) or IDH2 (R140/R172), which results in altered enzyme activity and promotes leukemogenesis through a variety of mechanisms 75