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In general, multiple models of membrane permeation, such as the “barrel-stave”, “carpet”, and “toroidal pore” models, have been proposed to describe the mechanism action of the mentioned peptides (117)
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The presence of αSyn was shown to expand the exocytotic fusion pore at the synapse, favouring full membrane fusion over the faster “kiss-and-run” mechanism (Khounlo et al., 2021)
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