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The assay uses tester strains with different mutation targets so that base-substitution and frameshift mutagens can be detected, and testing is performed with and without exogenous mammalian metabolic activation because some chemicals require biotransformation to become mutagenic
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For example, mitochondrial nicotinamide mononucleotide adenylyltransferase and mitochondrial NADK support NAD + and NADP + synthesis, respectively, in this organelle (10, 71, 118)
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