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For multimodal muscle axis combining the multiple targets involved in resolving the muscle injury and maintaining function this might be a well-functioning cytoprotection loop (i.e., brain-periphery), where an upgrading of a minor vessel compensates and takes over the function of the disable major vessel and reestablishes the reorganized blood flow [5,6,66,71,72,73,74,75,76,77,78,79,80,81,82]