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a myostatin inhibitor e.g., an anti-myostatin antibody or antigen-binding fragment thereof disclosed herein a metabolic disease or disorder e.g., metabolic syndrome, obesity, type 2 diabetes, or type 2 diabetes associated with obesity Examples of the diet regimen include, but are not limited to, caloric restriction (e.g., reduced calorie intake or reduced absorption of calories), diets with modified nutrient content (e.g., high protein, low fat, low carbohydrate, keto, paleo, etc.) or modified timing of food intake (e.g., intermittent fasting, increased frequency of feeding, etc.) or a combination of modified timing, portion size, and nutrient content (e.g., more frequent meals of smaller portions containing high protein, low fat, and/or other nutrient content restrictions)