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The entire screening process is based on a nontargeted analysis method, including nontargeted data acquisition with full scan mode, nontargeted ion extraction using molecular features, and automatic isotope ion pair picking, which can minimize the discriminatory treatment of metabolite information and enable comprehensive data mining

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10 mg per month), developed an itchy rash and widespread urticarial lesions over the entire body approximately 30 min after the 10th injection