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Similarly, folate and B12 supplementation have been shown to enhance leukocyte and mucosal DNA methylation in colorectal adenoma cohorts, confirming that methyl-donor interventions can modulate the human methylome

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What we know Three pooled analyses of randomized controlled trials found no benefits of vitamin C supplementation, alone or in combination with other supplements, on pregnancy adverse events (preeclampsia, congenital malformations, stillbirth, perinatal death, preterm birth), with the exception of a reduced risk of placental abruption and a significant increase in gestational age at birth