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It is becoming more widely recognized that variations in epigenetic modification lead to aberrant neuroendocrine responses, loss of neuroplasticity, neurotransmission, and dysfunction of neuroglia, all of which have been associated with the etiology of MDD and stresses such as anxieties and post-traumatic stress disorder (PTSD) (196, 197)
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Other possible explanations for the discrepancy could be the different methods used to determine G protein activation and arrestin translocation [GTP γ S binding and an arrestin complementation assay by McPherson et al
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