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156 Apoptosis Excessive intracellular ROS activate proapoptotic BH3-only proteins (e.g., BAD, BIM, PUMA, NOXA), which displace antiapoptotic BCL-2 family members (e.g., BCL-2, BCL-XL), enabling BAX/BAK activation and mitochondrial outer membrane permeabilization (MOMP)
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