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In addition, HSPB1 can inhibit TFRC-mediated iron uptake ( Aconitase 1 and Iron-Responsive Element Binding Protein 2 Cellular iron homeostasis is tightly regulated at the posttranscriptional level by iron regulatory proteins (IRPs), including aconitase 1 (ACO1/IRP1) and iron-responsive element binding protein 2 (IREB2/IRP2), to adapt to a change of iron levels (Figure 2)
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