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Lithium therapeutic mechanisms remain complex, including several pathways and gene expression, such as neurotransmitters and receptors, circadian modulation, ion transport, and signal transduction processes 20
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However, the glutamine utilization rate exceeds nucleic acid synthesis by more than an order of magnitude in proliferating cells, and thus nitrogen donation to nucleotides accounts for only a small fraction of total glutamine consumption (Ardawi et al
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