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NRF2 and the Hallmarks of Cancer: Cancer Cell

This imbalance leads to widespread oxidative damage, including lipid peroxidation, which destabilizes neuronal membranes, protein oxidation, which results in the accumulation of toxic aggregates, and DNA damage, which triggers cell-death pathways [35,65,66,67,68,69,70] (Figure 1)

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Hence, there has been an increasing trend of recent studies investigating the sequenced or combined application of GSH with different bioactive(s), which can be categorized into three main types: plant metabolites (primary & secondary) and biostimulants