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Astrocytes are the primary producers of C3 in the CNS, and numerous studies have highlighted how astrocytic C3 is associated with worse pathology in MS and EAE 50,157–159
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Polymorphisms in various genes involved in vitamin B 12 metabolism, including the genes encoding the intrinsic factor-cobalamin receptor (60) and the holo-transcobalamin receptor (61), have been associated with increased NTD risk in some studies
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