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A three-year trial of DHA supplementation (800 mg/day) in elderly adults without dementia is currently under way (see www.clinicaltrials.gov)
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Thus, absence of GPx1 in knockout mice was found to augment neuronal damage in the middle cerebral artery occlusion ischemia-reperfusion (MCAO) model of stroke, with increased infarct volume and increased apoptosis in brains of GPx1 −/− mice compared with wildtype mice [106]
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