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Taken together, these results suggest high selectivity of the small molecule 5-amino-1MQ analogue at pharmacologically relevant concentrations to NNMT-inhibition
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However, when hyperhomocysteinemia was simulated and a cysteine-block applied (Figure 6B), it prevented a significant elevation in cytosolic GSH levels: GSH levels deviate by only about 10% from the steady-state at nominal values of and
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