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On the direct evidence, the position is pretty blunt: there is no published human trial of the two together, no combination toxicology, and no convincing indexed animal study showing the pair outperforms either peptide alone
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Damage to the blood-brain barrier (BBB) in the CNS around the site of inflammation can result in an uncontrolled release of metalloproteinases, inflammatory cytokines, and proteases and the inappropriate activation and dysfunction of endothelial cells and extravasation of oedema fluid into the interstitial space [9]
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