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Taken together, while several interventions show biological plausibility and early clinical signals, PRP is the only modality in our reference set that consistently approaches higher-tier evidence under the OCEBM 2011 framework, whereas the remaining modalities should be interpreted with moderate-to-low confidence pending larger, methodologically standardized randomized trials with longer follow-up and stronger safety reporting
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Moreover, Mistry and his colleagues demonstrated that not only Lf, but also lactoferricin peptide, which is an N -terminal fragment of Lf formed after its digestion by pepsin, was observed with antiviral effects against HPV-5 and HPV-16
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