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150–153 In animal models with reduced F/B ratios, the expression of mucin and ZO-1 in the intestinal barrier, as well as the expression of anti-inflammatory factors, is increased, whereas the expression of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 is inhibited, and disease symptoms are largely reversed
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This therapy targets the immune system, specifically by addressing CD8 + T cells surrounding the hair follicles
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