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Common side effects: - Significant appetite increase (most common complaint) - Water retention and bloating, especially in the first 2-4 weeks - Mild muscle cramps or joint stiffness - Lethargy or drowsiness (particularly at higher doses) - Numbness or tingling in extremities Important metabolic concerns: - MK-677 can reduce insulin sensitivity and raise fasting blood sugar - This effect is dose-dependent and more pronounced at higher doses - People with prediabetes or diabetes should exercise significant caution - Regular glucose and insulin monitoring is important - Some providers recommend metformin alongside MK-677 to counteract insulin effects MK-677 vs injectable GH peptides (side effect comparison): - More appetite increase than Ipamorelin - More water retention than CJC-1295/Ipamorelin - More impact on insulin sensitivity - But no injection pain, no reconstitution calculator, no injection site management - Simpler protocol compliance Who should avoid MK-677: - People with diabetes or significant insulin resistance - Those actively trying to lose weight (appetite increase counterproductive) - People with active cancer - Pregnant or breastfeeding women Discuss the with your provider to find the best fit

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