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A renaissance of its use followed at the beginning of the 20th century with personalities like Queen Victoria and Empress Sissi, who used it for its antitussive properties and appetite stimulation ( 9 -tetrahydrocannabinol (THC), which was discovered in 1964 (Gaoni and Mechoulam, 1964), followed by the discovery of cannabinoid receptors and in 1992 also the discovery of endocannabinoids (Devane et al., 1992)
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