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By use of GRK overexpression and knockdown methods in HEK293 cells, the same group recently reported DAMGO-induced phosphorylation of Thr370 and Ser375 is catalyzed by GRK2 and GRK3, but morphine-induced phosphorylation of Ser375 is predominantly mediated by GRK5 (Doll et al., 2012)
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However, other protocols of cortical lesions may induce local neurogenesis with neuronal maturation and long-lasting stable network integration (Magavi et al., 2000) induced synchronous apoptotic degeneration of layer VI corticothalamic projection neurons by targeting neuronal degeneration with chromophores
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