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It has been demonstrated that FOXO4-DRI can directly and with high affinity binds to the transactivation domain 2 (TAD2) of p53, competitively disrupting the FOXO4-p53 interaction within the nucleus
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Hyperinsulinemia causes reduced hepatic synthesis of insulin-like growth factor (IGF)-binding protein-1 and increased bioavailability of IGF1, which further promotes cellular proliferation and inhibits apoptosis [10, 34]
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