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Thus, in the early 1990s, pentadecapeptide BPC 157[1,7] appeared as a late outbreak of the cytoprotection-organoprotection concept of Robert and Szabo[14-16,18,19], for epithelial and endothelial protection, like the previous theoretical/practical breakthrough in the 1980s[14-16,18,19] and the brain-gut axis and gut-brain axis[3]

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Here, the high-affinity copper(II)-binding tripeptide GHK was fused to the N-terminus of a GFP variant and an MBP-FG peptide fusion