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Men are also more likely to develop conditions associated with reduced glutathione or higher oxidative stress, including, More visceral fat than women, which drives insulin resistance 49 Higher rates of sleep apnea, another contributor to oxidative stress 50 Cardiovascular disease, which occurs about 7–10 years earlier in men than in women on average 51 As estrogen declines through perimenopause and menopause for women—and remains lower in men overall—differences in glutathione activity likely reflect hormonal influence as much as sex-based biology, Tennant says