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Karaa A., Bertini E., Carelli V., et al., “Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The Mmpower‐3 Randomized Clinical Trial,” Neurology 101 (2023): e238–e252

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We first identified that dietary activation of NRF2 by SF is still maintained during excess glucose [48] and showed for the first time that SF is indeed a metabolic regulator and specifically interferes with the metabolism of glutamine and cysteine along with serine and glycine in 1C metabolism, interconnected with its ability to increase antioxidant cellular capacity