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GPCRs are expressed in almost all cell types of the human body, and are generally grouped into four families based on the sequence homology and functional similarity: class A (rhodopsin-like), class B (including the secretin-like B1, and adhesion B2 subtypes), class C (metabotropic glutamate/pheromone receptors), and class F/O (frizzled/smoothened receptors) ( Class A represents the largest family, and is further divided in three subgroups, namely, group 1 including rhodopsin and β-adrenergic receptors with the binding site located within the transmembrane segment
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