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44 An open-label, uncontrolled trial in 51 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) found improvements in 34 patients after 3 months of supplementation with hydroxo-B12, 10 000 mcg twice per week as nasal drops
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Expression of transporters of these amino acids (SLC1A5, SLC43A1, SLC3A2, LAT1) as well as BCAT1, which is involved in BCAA catabolism, were downregulated upon metformin treatment (Figure 3F-H and S3H, I)
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