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They don't require FDA approval but must follow compounding regulations under Sections 503A and 503B of the Federal Food, Drug, and Cosmetic Act
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They are not interchangeable, and the more interesting question is not "which wins?" but "do they reinforce each other?" This article compares the two on mechanism, evidence, and practical use — and then examines the documented and theoretical basis for combining them, including the important safety limits
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